|| Aspergillus fumigatus|
||Animal pathogen; human pathogen; toxic for animals; toxic for humans|
||Genus name: to scatter.
Species epithet: smoky.
|Alternative Species Name(s):||Neosartorya fumigata, which is the name of the teleomorph of this fungus, should not be used, however, as the anamorph name Aspergillus takes precedence for the entire genus Aspergillus. Which is decided by the fungal community.|
|Significance:||A. fumigatus is particularly worrying in the poultry industry because the animals in large flocks can be exposed to large amounts of spores and then suffer from disease.
|The colonies are greyish to blue-green in colour and have a cotton or wool-like texture. A single colony con cover the complete surface of an agar plate in a couple of days.
||The conidia are greyish green and 2-3 µm in diameter,
||Asparagillus spp. are aerobic and chemorganoheterotrophic organisms. They are extremely important in degrading organic matter in nature.|
|Reproduction:||Förökar sig huvudsakligen med konidier, som produceras i tusental och är luftburna. Kan dock även föröka sig sexuellt genom askosporer.|
||A. fumigatus is thermotolerant and can grow at a temperature up to 55°C. Conidia will survive at temperature up to 70°C.|
||A. fumigatus is ubiquitous in the environment and can be found in soil and decaying organic material (e.g. in compost heaps).|
||Aspergillosis is mainly an airway infection, affecting individuals with weakened immune systems and poultry that often live in an environment with a large amount of spores in the air.
|Hosts/substrate||Disease/effect||Clinical picture or result|
|Poultry and other birds kept in captivity||Aspergillosis (brooder pneumonia)||Respiratory infection|
|Ruminants||Aspergillosis||Bovine mycotic abortion|
|Horse||Aspergillosis||Guttural pouch mycosis|
|Humans with a normal immune system.||Aspergillosis||Respiratory infection|
|Humans with a weakened immune system||Invasive aspergillosis||Infection, which spreads from the lungs to other organs (brain, heart, kidneys and skin).|
||Mykotoxiner: fumitromogener, verruculogen och gliatoxin.|
||Diagnosis based on culture is not sufficient, as Aspergillus spp. can be isolated from the nasal cavity of healthy animals and they (and we) are constantly exposed to spores of these organisms.|
A. fumigatus är haploid.
|ACC-No GenBank||Strain/Isolate||# of chrom||Size (Mbp)||Ref|
|GCA_000002655 ||Af293 ||8 ||29.4 ||# 2|
|Mitochondrial DNA sequence:
|ACC-No GenBank||Strain/Isolate||Number of BP|
|NC_017016 ||A1163 ||30 696 |
|18S rRNA Seq:
|ACC-No GenBank||Strain/Isolate||Number of NT|
|LC485158 ||ATCC 13073 ||1733 |
|ACC-No GenBank||Strain/Isolate||Number of NT||Genes|
|NC_121481 ||ATCC 1022TM ||707 ||18S rRNA, ITS 1, 5.8S rRNA, ITS 2, 28S rRNA |
||Aspergillus is a very large genus, which consists of about 250 species.
|Comment:||A. fumigatus is both a primary pathogen and an opportunistic pathogen, but also a very important allergen.
Aspergillos can also be caused by the closely related species: närbesläktade arterna: A. flavus, A. niger, A. nidulans and A. terreus, which, however, is more unusual.
||No. 4, 9, 20|